Description
PT-141 Peptide: Melanocortin Receptor Agonist for Sexual Function Research
PT-141, also known as Bremelanotide, is a synthetic peptide derived from α-melanocyte-stimulating hormone (α-MSH) and studied for its effects on sexual arousal, desire, and central nervous system signalling. Unlike phosphodiesterase inhibitors, PT-141 acts primarily through the central melanocortin receptor system, rather than directly affecting peripheral blood flow. PT-141 has been investigated in both male and female research models for conditions involving hypoactive sexual desire, erectile dysfunction, and altered sexual motivation. Its mechanism involves activation of melanocortin receptors (MC3R and MC4R) in the brain, which are associated with sexual behaviour, mood, and reward pathways. Due to this central mode of action, PT-141 is often studied as a distinct alternative to vasodilatory compounds in sexual health research.
Product Summary Table
| Peptide Name | PT-141 (Bremelanotide) |
| Peptide Class | Melanocortin receptor agonist |
| Primary Targets | MC3R and MC4R receptors |
| Mechanism of Action | Central nervous system melanocortin signalling |
| Form | Lyophilised synthetic peptide (must be reconstituted) |
| Research Vial Format | 10 mg |
| Country of Origin | Australia |
| Storage | Lyophilised: store cold and protected from light; Reconstituted: 2–8°C |
| Standard | Research Grade Purity ≥98 percent |
In Vivo Research Benefits
PT-141 has been evaluated in controlled clinical and preclinical studies examining sexual function and neurobehavioural responses.
- Increased sexual arousal observed in both male and female research participants.
- Central modulation of sexual desire independent of nitric oxide pathways.
- Improved erectile response in male models through CNS-mediated signalling.
- Enhanced sexual motivation linked to melanocortin receptor activation.
- Distinct mechanism compared to PDE5 inhibitors such as sildenafil.
Benefits of PT-141 Peptide
- Central Nervous System Action targeting sexual desire pathways.
- Applicable to Both Sexes in sexual function research models.
- Non-Vasodilatory Mechanism unlike traditional erectile dysfunction agents.
- Well Studied Melanocortin Pathway with human clinical trial data.
- Unique Peptide Profile for sexual health and behavioural research.
Studies and Additional Info
- Clinical trials investigating PT-141 in hypoactive sexual desire disorder
- Research on melanocortin receptor signalling and sexual behaviour
- Comparative studies versus PDE5 inhibitors
- Neuroendocrine and CNS pathway analyses involving α-MSH derivatives
Disclaimer: PT-141 is supplied strictly for laboratory research purposes. It is not intended for human consumption or therapeutic use.
Frequently Asked Questions
What is PT-141 studied for?
PT-141 is studied for sexual arousal, libido regulation, and central nervous system signalling related to sexual behaviour.
How does PT-141 differ from Viagra or Cialis?
PT-141 acts centrally through melanocortin receptors in the brain, while PDE5 inhibitors act peripherally by increasing blood flow.
Is PT-141 studied in both men and women?
Yes. Research includes both male and female models, particularly in studies of sexual desire and arousal.
Does PT-141 affect blood pressure?
Some studies report transient effects such as nausea or changes in blood pressure, which are monitored in clinical research settings.
Is PT-141 approved for general human use?
No. PT-141 is supplied for research purposes only and is not approved for general human consumption.



