Description
Ipamorelin: Growth Hormone Secretagogue for Endocrine and Metabolic Research
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue studied for its ability to selectively stimulate growth hormone (GH) release from the anterior pituitary gland. It functions through activation of the ghrelin receptor (GHS-R1a), mimicking endogenous ghrelin signalling while maintaining a high degree of specificity for GH secretion. Unlike earlier growth hormone releasing peptides, Ipamorelin has been characterised by its minimal interaction with cortisol, prolactin, and other pituitary hormones, making it a compound of interest in research focused on targeted GH modulation and endocrine balance.
Research into Ipamorelin examines its role in growth hormone pulsatility, tissue repair pathways, body composition regulation, and metabolic signalling. Due to its selective receptor profile, Ipamorelin is frequently studied as a comparator compound alongside other GH secretagogues and GHRH analogues.
Product Summary Table
| Peptide Name | Ipamorelin |
| Peptide Class | Growth hormone secretagogue (GHS) |
| Primary Target | Ghrelin receptor (GHS-R1a) |
| Mechanism of Action | Selective stimulation of pituitary growth hormone release |
| Amino Acid Length | 5 amino acids (pentapeptide) |
| Form | Lyophilised synthetic peptide (must be reconstituted) |
| Research Vial Format | 5 mg |
| Country of Origin | Australia |
| Storage | Lyophilised: store cold and protected from light; Reconstituted: 2–8°C |
| Standard | Research Grade Purity ≥98 percent |
In Vivo Research Findings
Ipamorelin has been evaluated in preclinical and clinical research models examining growth hormone dynamics and endocrine signalling.
- Selective growth hormone release with minimal impact on cortisol and prolactin levels.
- Preservation of natural GH pulsatility rather than continuous hormone elevation.
- Support of tissue repair pathways associated with GH and IGF-1 signalling.
- Metabolic regulation involving lipid mobilisation and protein synthesis pathways.
- Favourable tolerability profile compared to earlier GHS compounds.
Research Applications of Ipamorelin
- Endocrine Research focused on pituitary growth hormone regulation.
- GH–IGF Axis Investigation in metabolic and ageing models.
- Tissue Repair Studies involving connective tissue and muscle signalling.
- Comparative Secretagogue Research alongside GHRH analogues and other GHS compounds.
- Body Composition Research examining GH-mediated pathways.
Studies and Additional Info
- Clinical endocrinology research on ghrelin receptor agonists
- Studies examining Ipamorelin-induced GH release dynamics
- Comparative analyses with GHRP-2, GHRP-6, and GHRH analogues
- Research into selective pituitary hormone modulation
Disclaimer: Ipamorelin 5mg is supplied strictly for laboratory research purposes. It is not intended for human consumption or therapeutic use.
Frequently Asked Questions
What is Ipamorelin studied for?
Ipamorelin is studied for its ability to selectively stimulate growth hormone release via ghrelin receptor activation.
Does Ipamorelin directly contain growth hormone?
No. Ipamorelin does not contain GH; it stimulates endogenous GH release from the pituitary gland.
How does Ipamorelin differ from other GHRPs?
Ipamorelin is more selective for GH release and shows minimal stimulation of cortisol or prolactin compared to earlier compounds.
Is Ipamorelin a hormone?
No. Ipamorelin is a peptide secretagogue that influences hormone release rather than acting as a hormone itself.
Is Ipamorelin approved for human use?
No. Ipamorelin is supplied strictly for laboratory research purposes and is not approved for human consumption.




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