Description
Human Chorionic Gonadotropin (HCG): Gonadotropin Hormone for Endocrine and Reproductive Research
Human Chorionic Gonadotropin (HCG) is a naturally occurring glycoprotein hormone that plays a critical role in gonadal signalling, testosterone regulation, and reproductive endocrinology. Structurally and functionally similar to luteinizing hormone (LH), HCG binds to the LH/CG receptor in the testes, stimulating Leydig cells to produce testosterone. Due to this mechanism, HCG has been widely studied in research examining hypogonadism, fertility, post-suppression recovery, and hypothalamic–pituitary–gonadal (HPG) axis regulation.
In laboratory and clinical research contexts, HCG is utilised to investigate endogenous testosterone production and the maintenance of testicular function during periods of hormonal suppression. Its ability to directly stimulate the testes, independent of pituitary signalling, distinguishes it from selective estrogen receptor modulators (SERMs) and other endocrine modulators.
Product Summary Table
| Compound Name | Human Chorionic Gonadotropin (HCG) |
| Compound Class | Glycoprotein gonadotropin hormone |
| Primary Target | Luteinizing hormone / chorionic gonadotropin receptor (LH/CG receptor) |
| Mechanism of Action | Direct stimulation of Leydig cells to produce testosterone |
| Biological Focus | Testosterone production and reproductive endocrine signalling |
| Form | Lyophilised peptide hormone (must be reconstituted) |
| Country of Origin | Australia |
| Storage | Lyophilised: store cold and protected from light; Reconstituted: 2–8°C |
| Standard | Research Grade |
In Vivo Research Findings
HCG has been extensively evaluated in endocrine and reproductive research models.
- Stimulation of intratesticular testosterone production via LH receptor activation.
- Maintenance of spermatogenesis in hypogonadal and suppression models.
- Preservation of testicular volume during androgen suppression studies.
- Increased sperm concentration and motility observed in fertility research.
- Support of androgen-dependent tissue function through endogenous testosterone signalling.
Research Applications of HCG
- Male Fertility and Spermatogenesis Research.
- Hypogonadism and Testosterone Recovery Studies.
- Post-Suppression Endocrine Recovery Models.
- HPG Axis Regulation Research.
- Comparative Studies with SERMs and GnRH Modulators.
Studies and Additional Info
- Clinical research on HCG and male fertility outcomes
- Studies examining Leydig cell stimulation and testosterone synthesis
- Research into gonadotropin signalling and testicular function
- Comparative endocrine recovery studies involving HCG and SERMs
Disclaimer: Human Chorionic Gonadotropin (HCG) is supplied strictly for laboratory research purposes. It is not intended for human consumption or therapeutic use.
Frequently Asked Questions
What is HCG studied for?
HCG is studied for its role in testosterone production, fertility, and reproductive endocrine signalling.
How does HCG differ from testosterone replacement?
HCG stimulates endogenous testosterone production rather than supplying exogenous testosterone.
Does HCG act on the pituitary gland?
No. HCG acts directly on the testes via the LH/CG receptor, bypassing pituitary signalling.
Is HCG a peptide or hormone?
HCG is a naturally occurring glycoprotein hormone.
Is HCG approved for human use?
While HCG has approved medical applications in regulated settings, the product supplied here is intended strictly for laboratory research purposes.



